Rishi Sunak, son-in-law of Infosys co-founder Ramarao Narayana Murthy, replaced Pakistani Chancellor Sajid Javid as the UK's Chancellor of the Exchequer (Treasury Secretary) on Thursday, while Alok Sharma was appointed Secretary of Commerce in the British cabinet.
There are now three MPs of Indian descent in Prime Minister Boris Johnson's cabinet.
According to media reports, the decision comes just a few weeks before the eight-month-old Javid should unveil the UK budget on March 11 and set out the government's tax and spending plans.
Rishi Sunak, the 39-year-old finance minister, is close to Boris Johnson.
In the meantime, Alok Sharma, the former Secretary of State for International Development, has been appointed Secretary of State for Economic, Energy and Industrial Strategy.
Alok Sharma, 51, will also become President of COP26, the United Nations' climate summit, to be held in Glasgow this November.
In 2016, he was appointed Prime Minister's Infrastructure Officer for India.
Shortly after Prime Minister Boris Johnson reshuffled the British cabinet, three Indian MPs, including the new Home Secretary Priti Patel, secured cabinet seats in Parliament.
Boris Johnson appointed Ms. Patel the new Home Secretary last July. Following the development, Foreign Minister S Jaishankar had congratulated his "good friend" Priti Patel on this occasion.
Ms. Patel was born to Gujarati parents who fled to Uganda in the 1960s. She is a controversial figure who has spoken out in favor of bringing the death penalty back and who previously asked to cancel the goal of foreign aid.
She had an international portfolio as development secretary in Prime Minister Theresa May's former government, but had to resign due to an extremely poorly advised freelance trip to Israel.